THOMAS CONRADS - Clinical Proteomics Facility

Conrads Lab Research Program

Armed with sequence information of the human and mouse genomes, a major aim of biological science is toward unraveling the underlying molecular events that lead to cellular function/dysfunction in disease with the goal of discovering better diagnostic markers and therapeutic targets. Proteomics aims to facilitate this process by applying newly developed methods and advanced analytical tools for the investigation of the protein complement en masse. Hence, our research interests lie in developing new technologies that bridge the fields of chemistry and biology with the focus of application of these developments for the characterization of proteomic changes associated with pathophysiology, ascribing to the philosophy that the most significant biomedical problems require creative multidisciplinary approaches for their solution. In practice, our research will utilize advanced mass spectrometry (MS) tools to conduct proteomic investigations of human disease. Our research will have three major focus areas that include: 1) global profiling of protein abundance changes, 2) global and targeted characterization of protein post-translational modifications, and 3) high-throughput (clinical) assay development based on the use of selected reaction monitoring MS.

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